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Digestive Health - Gastrointestinal Health - Colon Health
Natural Supplements And Treatments Aiding Digestive Process And Colonic Health
Digestive Health -
Natural Supplements And Treatments Aiding Digestive Process And Colonic Health
DGL Deglycyrrhizinated Licorice Tablets
760 mg, 100 tablets
Deglycyrrhizinated licorice, commonly abbreviated DGL, is an extract of the root of true licorice, Glycyrrhiza glabra, which has significantly reduced mineralocorticoid activity. Licorice has a number of medicinal properties, including peptic ulcer healing, anti-inflammatory, antimicrobial and antioxidant activities. Glycyrrhizinic acid and its metabolite, glycyrrhetinic acid, have mineralocorticoid-like, as well as testosterone-reducing, activities. The use of licorice for the management of peptic ulcer disease is associated with hypertension, water retension and hypokalemia. The removal of most of the glycyrrhizinic and glyceyrrhetinic acids yields a product without these undesirable effects.
The mechanism of action of the peptic ulcer-healing activity of DGL Deglycyrrhizinated Licorice is not entirely understood. DGL Deglycyrrhizinated Licorice was found to stimulate and/or accelerate the differentiation of glandular cells in the forestomach of the rat, as well as stimulate mucus formation and secretion. The stimulation of mucus secretion in the stomach is believed to account, at least in part, for the activity of DGL. DGL Deglycyrrhizinated Licorice contains some flavonoids that have antimicrobial activity, including activity against the ulcer-causing bacterium Helicobacter pylori. This too could account, at least in part, for DGL's activity. New substances are continually being discovered in licorice, and it is possible that some of these may also play a role in DGL's activity.
DGL Deglycyrrhizinated Licorice Research
Several studies in animals and humans have demonstrated positive effects from the use of DGL in gastric and duodenal ulcer conditions. DGL Deglycyrrhizinated Licorice, administered in chewable doses of 760 milligrams a day for one month, was significantly superior to placebo in reducing peptic ulcer size and in hastening healing in human subjects, compared with the placebo control subjects. DGL produced complete healing in 44% of those receiving it, compared with complete healing in 6% of controls.
Subsequent studies have shown that DGL Deglycyrrhizinated Licorice is about as effective as cimetidine and ranitidine for both treatment and maintenance therapy of gastric ulcers. Comparison studies have not been made with DGL and famotidine, lansoprazole, omeprazole and other more recent anti-ulcer drugs.
DGL Deglycyrrhizinated Licorice appears to confer significant protection against the gastric mucosal damage caused by aspirin and other nonsteroidal anti-inflammatory drugs. Gastric bleeding induced by aspirin intake can also be reduced with DGL supplementation.
DGL Deglycyrrhizinated Licorice has also demonstrated significant efficacy in the treatment of duodenal ulcers. In one study, 40 patients who had suffered from severe duodenal ulcers for four to 12 years (and who had experienced more than six relapses in the previous year) were treated with either 3 grams of DGL daily for eight weeks or with 4.5 grams daily for 16 weeks. All showed significant improvement, but more improvement was seen with the higher-dose regimen. None of the patients required surgery during a one-year follow-up period. In other research, DGL had a therapeutic effect in duodenal ulcers equal to that of cimetidine.
DGL Deglycyrrhizinated Licorice's protective activity is attributed by some to its ability to stimulate the formation and secretion of mucus. It has been shown, in rats, to stimulate epithelial proliferation in the forestomach. More recently, it has been demonstrated that several flavonoids that are present in DGL can inhibit Helicobacter pylori growth.
Sometimes called the great harmonizer, licorice root has a long history of use in Chinese medicine for a variety of conditions. For some people, the glycyrrhizin component of whole licorice can cause adverse reactions, particularly for those who have high blood pressure. However, a unique extract called deglycyrrhizinated licorice (DGL) is free of glycyrrhizin. DGL has had no significant reported adverse effects. It therefore avoids the adverse reactions to whole licorice, but retains its beneficial qualities.
DGL Deglycyrrhizinated Licorice has a unique ability to protect the digestive tract from corrosive stomach acids. Additionally, DGL increases the number of mucus-secreting cells in the stomach, providing an improved environment that is conducive to healing.103-110 These beneficial qualities make DGL a useful adjunct for overall support of the stomach and intestinal lining.
DGL Deglycyrrhizinated Licorice Tablets Supplement Facts
Serving Size 2 tablets
Servings Per Container 50
Amount Per Serving
Sodium 5 mg
Total carbohydrate 2 mg
Sugars <1 g
Deglycyrrhizanated licorice (DGL) 760 mg
(Glycyrrhiza glabra root extract, 3:1)
Glycine 100 mg
DGL Deglycyrrhizinated Licorice Tablets Other ingredients: fructose, mannitol, sorbitol, cellulose, stearic acid, magnesium stearate, silicon dioxide, and natural anise favor. Contains no yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, or preservatives.
DGL Deglycyrrhizinated Licorice Tablets Dosage and Use
Chew two tablets 20 minutes before each meal.
For support of the lining of the stomach and intestine, chew two 380-mg tablets three to four times daily between meals.
DGL Licorice Tablets - Protect Stomach Tract From Corrosive Acids
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